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Da Mi Ph.D.

Associate Professor

2001-2005 Nankai University, China/ B.S.
2005-2008 Nankai University, China/ M.Sc.
2008-2013 University of Edinburgh, UK/ Ph.D.
2013-2015 University of Edinburgh, UK/ Postdoctoral Fellow
2015-2020 King’s College London, UK/ Postdoctoral Fellow
2020-present School of Life Sciences, Tsinghua University, China/ Assistant Professor, Associate Professor
2020-present Center for Life Sciences & IDG/ McGovern Institute for Brain Research at Tsinghua University, Tsinghua University, China/ Principal Investigator

● Research interest：

The cerebral cortex is the seat of higher-order brain functions. It consists of a multitude of specialized, precisely positioned and interconnected cell types that assemble into specialized neuronal circuits. my research group is interested in how a small pool of neural progenitors generates the vast diversity of neuronal cell types during brain development, with a focus on mechanisms regulating initial cell fate decisions and neuronal diversification in the developing cerebral cortex. My team combines large-scale single-cell multi-omics techniques with a range of neuroanatomical, cell biological, molecular biological, genetic and transgenic methods to gain systematic understanding of the cellular and molecular mechanisms regulating the emergence of neuronal diversity in the developing cerebral cortex in rodents, non-human primates (NHPs) and human. In particular, we aim to uncover unique features of neuronal diversification in the human cerebral cortex. We also study the role of cellular heterogeneity in neurodevelopmental disorders and cell type-specific functions of disease susceptibility genes in cortical development.

● Selected publications：

1. Yang F, Zhao Z, Zhang D, Xiong Y, Dong X, Wang Y, Yang M, Pan T, Liu C, Liu Y, Tu Q, Dang Y, Xia M*, Mi D*, Zhou W*, Xu Z*. (2024) Single-cell multi-omics analysis of lineage development a spatial organization in the human fetal cerebellum. Cell Discovery,22 ,10 (1).

2. Fisher J, Vehagen M, Long Z, Mossidis M, Yan Y, He C, Wang J, Micoli E, Alastruey C, Moors R, Marin O*, Mi D*, Lim L*. (2024) Cortical somatostatin long-range projection neurons and interneurons exhibit divergent developmental trajectories, Neuron, 558-573.e8, 112(4)

3. Ma S, Skarica M, Li Q, Xu C, Risgaard RD, Tebbenkamp ATN, Mato-Blanco X, Kovner R, Krsnik Ž, de Martin X, Luria V, Martí-Pérez X, Liang D, Karger A, Schmidt DK, Gomez-Sanchez Z, Qi C, Gobeske KT, Pochareddy S, Debnath A, Hottman CJ, Spurrier J, Teo L, Boghdadi AG, Homman-Ludiye J, Ely JJ, Daadi EW, Mi D, Daadi M, Marín O, Hof PR, Rasin MR, Bourne J, Sherwood CC, Santpere G, Girgenti MJ, Strittmatter SM, Sousa AMM*, Sestan N*. (2022) Molecular and cellular evolution of the primate dorsolateral prefrontal cortex. Science 377 (6614), eabo7257.

4. Shi Y^#, Wang M^#, Mi D^#, Lu T, Wang B, Dong H, Zhong S, Chen Y, Sun L, Zhou X, Ma Q, Liu Z, Wang W, Zhang J, Wu Q*, Marín O*, Wang X*. (2021) Mouse and human share conserved transcriptional programs for interneuron development. Science. 10; 374.

5. Mi, D^#., Li, Z^#., Lim, L., Li, M., Moissidis, M., Yang, Y., Gao, T., Hu, T.X., Pratt, T., Price, D.J., Sestan, N., and Marín, O*. (2018) Early emergence of cortical interneuron diversity in the mouse embryo. Science. 360, 81-85.

6. Lim, L^#., Mi, D^#., Llorca, A., and Marín, O*. (2018) Development and Functional Diversification of Cortical Interneurons. Neuron. 100, 294-313.

7. Mi, D., Carr, C.B., Georgala, P.A., Huang, Y.T., Manuel, M.N., Jeanes, E., Niisato, E., Sansom, S.N., Livesey, F.J., Theil, T., Hasenpusch-Theil, K., Simpson, T., Mason, J., and Price D.J*. (2013) Pax6 Exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and Hypophosphorylation of pRb. Neuron. 78, 269–284.

● Award：

IBRO World Congress Trave Grant (2019)
Guarantors of Brain Travel Award (2019)
University of Edinburgh/ NeuroResearchers Fund Award (2014)
Member of British Neuroscience Association (2013-2019)

● Contact information：

Tel：010-62793866

E-mail：mida@mail.tsinghua.edu.cn